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Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth (Eagleson et al., 2016)

While researchers usually administer BPC-157 and TB-500 via injections, there are now nasal spray blends on the market

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Table 5 also lists the raw effect size (not counting placebo effect) and the estimated net effect size (using the placebo effect from the Adams 2011 study)